Greenville is accessible via Interstates 85, 185 and 385, as well as U.S. highways 25, 29, 123 and 276.
Operated by the City of Greenville, under contract to the Greenville Transit Authority, Greenlink provides fixed route and ADA transportation services throughout Greenville County. Greenlink also operates the CU-ICAR/St. Francis Shuttle and owns and operates Greenville's downtown trolleys.
Greyhound provides interstate bus service to cities throughout the Southeast.
Greenville is served by two major commercial railroads, Norfolk Southern and CSX Corporation. Passenger rail service is provided by Amtrak, with connections to several major cities.
Located just 20 minutes from downtown Greenville, Greenville-Spartanburg International Airport(GSP) serves more than 1.8 million passengers per year with six major airlines offering 49 non-stop average daily departures to 15 major cities and 18 airports across the U.S.
Greenville Downtown Airport (GMU) is the busiest general aviation airport in South Carolina, with more than 48,000 take-offs and landings each year. Just a few miles from downtown, GMU offers a full range of aviation services to support the Upstate's business environment.
The South Carolina Inland Port opened in Greer in 2013, extending the reach of the Port of Charleston 212 miles inland. The port is located within a few miles of GSP.
Bikeville is the City of Greenville's bicycle friendly community initiative. The League of American Bicyclists honored Greenville with its prestigious Bicycle Friendly Community award (Bronze Level) in 2009 and again in 2013, citing its city-wide bike network, downtown bike parking, racks on all Greenlink buses and bike-sharing B-Cycle program.
Greenville B-Cycle network has eight stations and 35 bikes. Members can check out a bike and return it to any of the following conveniently located stations: the Greenville Zoo, Hughes Main Library, County Square, Sterling Community Center, City Hall, Greenville Transit Center and at the corners of College and North Main Street and Rhett and River Streets.